7/6/2023 0 Comments Hexavalent chromiumThe European Commission conducted a socioeconomic, health, and environmental impact assessment and found that strong factors related to attributable cancer deaths include hardwood dust, Cr(VI), and respirable crystalline silica ( 2). In addition, there is sufficient evidence that Cr(VI) is related to cancers of the lung, nasal cavity, and paranasal sinuses ( 1). According to data from the International Agency for Research on Cancer (IARC), hexavalent chromium has been classified as a Group I occupational carcinogen. It is essential to recognize and identify occupational carcinogens for risk prevention, surveillance, and compensation of exposed workers. Occupation-related cancers are an important public health issue with serious socioeconomic effects. In addition, there was a strong association between incidence and mortality risk of cancers and concentration of Cr(VI) in the air and the exposure time. Cr(VI) exposure was related to an elevated risk of respiratory system, buccal cavity, pharynx, prostate, and stomach cancers.Ĭonclusions: Cr(VI) might cause cancers of the respiratory system, buccal cavity and pharynx, prostate, and stomach in humans, and it is related to increased risk of overall mortality owing to lung, larynx, bladder, kidney, testicular, bone, and thyroid cancer. Summary SIRs were elevated among cement industry workers and tanners. In the subgroup analysis, Cr(VI) exposure was related to a higher risk of death owing to lung, larynx, bladder, kidney, testicular, bone, and thyroid cancer. Summary SMRs were higher among chromate production workers, chrome platers, and masons, and especially male workers. The summary SMR for all studies combined was 1.07 (95% CI: 1.01–1.15). Results: A total of 47 cohort studies covering the period 1985–2016 were included (37 studies reporting SMRs and 16 studies reporting SIRs). Subgroup analyses were conducted by sex, occupation, and types of cancer to identify groups that were at high-risk or predisposed to certain cancers. Methods: We performed a search of the literature and extracted the standardized mortality ratios (SMRs), standardized incidence ratios (SIRs), and their corresponding 95% confidence intervals (CIs), to estimate risk values. Objectives: In this meta-analysis, we aimed to evaluate the relationship between exposure to Cr(VI) and the mortality and incidence of human cancers. 3Department of Epidemiology and Biostatistics, Xi'an Jiaotong University Health Science Center, School of Public Health, Xi'an, Chinaīackground: Hexavalent chromium is an occupational carcinogen that can cause lung and nasal cancers, but its association with mortality and incidence in many other cancers is unclear.2Department of Oncology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.1Department of Breast Surgery, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.Yujiao Deng 1,2 †, Meng Wang 1,2 †, Tian Tian 1,2 †, Shuai Lin 1, Peng Xu 1, Linghui Zhou 1, Cong Dai 1, Qian Hao 1, Ying Wu 1, Zhen Zhai 1, Yue Zhu 1, Guihua Zhuang 3 * and Zhijun Dai 1,2 *
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